Bacterial warfare again targets the ribosome.
نویسندگان
چکیده
In this issue of Structure, Beck and colleagues describe the structure of the Enterobacter cloacae contact-dependent growth inhibition (CDI) toxin in complex with its immunity protein. Further functional studies reveal that CDI targets translation by cleaving 16S ribosomal RNA.
منابع مشابه
Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome
The antibiotic drug fusidic acid (FA) is commonly used in the clinic against gram-positive bacterial infections. FA targets ribosome-bound elongation factor G (EF-G), a translational GTPase that accelerates both messenger RNA (mRNA) translocation and ribosome recycling. How FA inhibits translocation was recently clarified, but FA inhibition of ribosome recycling by EF-G and ribosome recycling f...
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Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome. The aminoacyltRNA synthetases that activate each amino acid required for peptide synthesis are not antibiotic target...
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The 2001 anthrax mail attacks in the United States demonstrated the potential threat of bioterrorism, hence driving the need to develop sophisticated treatment and diagnostic protocols to counter biological warfare. Here, by performing flux balance analyses on the fully-annotated metabolic networks of multiple, whole genome-sequenced bacterial strains, we have identified a large number of metab...
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Many clinically useful antibiotics interfere with protein synthesis in bacterial pathogens by inhibiting ribosome function. The sites of action of known drugs are limited in number, are composed primarily of ribosomal RNA (rRNA), and coincide with functionally critical centers of the ribosome. Nucleotide alterations within such sites are often deleterious. To identify functional sites and poten...
متن کاملCLINICAL PRESENTATION OF CHEMICAL WARFARE INJURIES IN CHILDREN AND TEENAGERS
Clinical manifestations of sixteen children and teenagers exposed to chemical warfare in Halabje are presented. 15 patients complained of burning of skin. Dry coughing was present in 13 subjects. The most frequent signs were conjunctivitis, skin erythema, edema of the eyelids, hyperpigmentation, ulceration, erosion, dyspnea, closure ofthe eyes, blisters, edema of the skin, and crepitation ...
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عنوان ژورنال:
- Structure
دوره 22 5 شماره
صفحات -
تاریخ انتشار 2014